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elegans utilises dietary heme to provide this prosthetic group to endogenous heme proteins and potentially as an iron source in conditions of environmental iron deficiency [169]

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The full inclusion and exclusion criteria have been published [30]

Substrate preferences for BCAT proteins is isoleucine, leucine and then valine (Wallin et al., 1990

Whether these alterations are the basis of the disease or a homeostatic response to the disorders remains to be clarified

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