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Conversion de lhomocystine en mthionine , dans le cytoplasme cellulaire via la mthionine synthase, enzyme qui ncessite la mthylcobalamine comme cofacteur, entranant une accumulation dhomocystine plasmatique en absence de B12

They might start with lower doses to avoid side effects

Spiering, B

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Wei K, Korsunsky I, Marshall JL et al (2020) Notch signalling drives synovial fibroblast identity and arthritis pathology

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