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Although the use of PQ is banned by many countries due to its fatal toxicity towards humans, its manufacture and exportation are controversially permitted (Bastias-Candia et al., 2012

A 2016 comparative study published in Nature Scientific Reports demonstrated that GHK-Cu produced no cytotoxicity to human keratinocytes at concentrations up to 5,800 micromolar over 72 hours and did not induce inflammatory biomarkers, unlike other copper compounds tested alongside it

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