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If nasal delivery achieves effective central appetite suppression at lower total systemic doses than injection, the cost per therapeutic outcome could potentially favor the nasal route despite lower bioavailability

Currently, the analysis of biomarkers of apatinib in the treatment of GC after chemotherapy is mainly based on serum VEGFR-2 (95), serum carbohydrate antigen 19-9, carcinoembryonic antigen (CEA), tumor supplied group factor (TSGF), tumor necrosis factor- (TNF-) and inflammatory factors (105, 107)

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