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Although peripheral AC levels may not directly reflect brain-specific alterations, their role in systemic energy balance suggests an impact on central processes like mood regulation [18]

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More specifically, the high-risk plaques showed signs of reduced FAO (with a decrease in short-chain acylcarnitines) but increased glycolysis (with reduced levels of glucose but increased lactate) and amino acid use (with reduced substrates of glutamine and serine) (Tomas et al., 2018)

Traditionally, AMD has been classified broadly into two clinical sub-types

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