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13,95,96 Disruption of metabolic pathways exacerbates inflammatory responses and oxidative stress

In a murine model of B16F10 melanoma expressing both VEGF-C and chicken ovalbumin (OVA), overexpression of VEGF-C in cancer cells promotes lymphangiogenesis in both primary tumors and TDLNs, leads to CD8+ T cell immune tolerance via LEC cross-presentation ( Figure 1 ), protects tumors against preexisting anti-cancer immunity, and promotes the local elimination of OVA-specific CD8+ T cells (93)

Yeast strains carrying a conditional mutation in Ero1 were compromised in their ability to form disulphide bonds in secreted proteins when grown at the nonpermissive temperature

Weight, lipids, A1c, liver enzymes, NAFLD Fibrosis score (NFS) and imaging data were obtained at baseline and yearly for up to 5-years post-surgery via retrospective chart review

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