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Dysregulation of copper homeostasis interferes with the PARKIN/PINK1 pathway through multi-layered mechanisms (125)

Although MCHM has been linked to DNA damage, we did not observe an increase in mutations in treated cells

Proc Natl Acad Sci 118:e2101708118

Vitamin B3 (nicotinamide) was effective in ALS mice via Akkermansia , and now nicotinamide is being trialed in ALS patients at high doses to see if it slows progression [83, 267]