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295 Obesity may play a contributing role in fibromyalgia, and weight loss has been associated with reduced pain in people with fibromyalgia

Hou C, Wang Y, Zhu E et al (2016) Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer

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Notably, Nrf2 translocates to the nucleus in ROS-sensitive cells, increases the antioxidant HO-1 levels, decreases the MDA levels, and increases the SOD and GSH activities ( The combination of artesunate and dihydroartemisinin downregulates PERK, ATF4, and CHOP, reduces Fe 2+ concentration, attenuates iron-induced cell death, and ameliorates lung injury ( 2+ levels by inhibiting the PRIM2/SLC7A11 axis ( Artesunate may inhibit the proliferation of lung cancer cells, downregulate the expression of anti-apoptotic molecules Bcl-2 and survivin, upregulate the expression of pro-apoptotic molecules P53 and Bax, and increase the activity of caspases and apoptosis rate through the PPAR-/TGF-1/Smad2/3, AKT/Survivin, P38/JNK/ERK, and MAPK pathways ( Dihydroartemisinin inhibited the proliferation of A549 and HCC827 cells in a dose-dependent manner

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Colao et al