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Why Angiogenesis Matters Angiogenesis, the formation of new blood vessels, is vital for healing after injury

The antioxidant system, encompassing elements like catalase (CAT) and glutathione (GSH), endeavors to neutralize the damaging ROS but often gets overwhelmed in the process of sepsis, aggravating tissue damage and propelling the inflammatory response 13

10.1002/advs.202100241 34 KuermanbayiS.YangY.ZhaoY.LiY.WangL.YangJ.et al (2022)

Jurkat cells were treated without (Green) or with 1 M staurosporine (Red) in 37C for 4 hours, and then ed with Annexin V-mFluor Violet 450 conjugate for 30 minutes

Activated neutrophils secrete myeloperoxidase (MPO), neutrophil elastase (NE), protease 3, histamine and matrix metalloproteinase 9 (MMP-9), all of which increase OxS, promote liver injury and the proliferation of hepatic stellate cells (HSCs), thereby increasing liver fibrosis 123,124

NAC helps with mucolysis and improving mucociliary clearance