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In vitro , 6p demonstrated potent inhibitory effects against non-small cell lung cancer (NSCLC) (A549, NCI-H1299) and melanoma (A375) cells, while sparing normal cell lines

10.1016/J.CRPHAR.2022.100149 151 RayP

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Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity

Once stabilized, HIF- translocates to the nucleus, dimerizes with HIF-1/Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT), and forms a HIF transcription factor to promote cellular pathways influencing proliferation and malignant progression (156158, 164)