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Platelets play a central role in this process by recognising exposed collagen at the injury site binding to fibrinogen to recruit additional platelets and form platelet aggregates, and initiating fibrin gel formation through activation of the coagulation proteolytic cascade 1

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Indeed, several studies have reported that immunosuppression induced by exercise excess can increase the risk of infections and the development or aggravation of overtraining syndrome (Reference Gleeson, Pyne and Elkington76,Reference Edouard, Junge and Sorg77)

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