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No significant differences were observed across metabotypes in TMAO AUC change between placebo and pomegranate interventions (Supplementary Figure 3), but mean TMAO AUC values differed between metabotypes following pomegranate intervention (Supplementary Figure 4)

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Transcriptional and post-transcriptional regulation of the genes encoding the small GTPases RhoA, RhoB, and RhoC: implications for the pathogenesis of human diseases