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The localized freezing can cause the same mechanical stress as freezer storage

The SATURN study subsequently compared rosuvastatin 40 mg versus atorvastatin 80 mg and showed a similar magnitude of plaque regression with the two regimens (1.22% [1.52 to 0.90] vs 0.99% [1.19 to 0.63]

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The numerator thresholds were developed according to evidence and consensus-based clinical guidelines for ED time thresholds, including guidelines developed by The Joint Commission (TJC), the American College of Emergency Physicians (ACEP), and the Emergency Department Benchmarking Alliance as well as input from a TEP, literature reviews, and environmental scans

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It should be noted that loss of dgtr-1 function caused highly penetrant embryonic arrest of otherwise wild type worms (Carvalho et al., 2011)