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Moreover, HGF prevents NMDA-induced neuronal death in hippocampal neuron cultures in vitro by blocking pro-apoptotic caspase-3 activation and translocation of AIF into the nucleus (Ishihara et al., 2005)

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Modulated genes included those involved in GABA transport, serotonin receptor expression, and immune signaling

Johnson M, Koukoulis G, Kochhar K, Kubo C, Nakamura T, Iyer A (Sep 1995)

Surez-lvarez, B., Liapis, H., & Anders, H.-J

This matters for any peptide, but it matters especially for compounds targeting the brain and endocrine system