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However, for glutamate export to occur cystine import is mandatory, thus the increased intracellular levels of cysteine must be relevant for cancer poor prognosis

Current challenges in NADs development Unlike traditional small molecules and antibody drugs that exert their pharmacological effects on proteins, most NADs directly regulate gene expression, offering a broader range of targets

[DOI] [PubMed] [Google Scholar] 93.Solomon B, Varella-Garcia M & Camidge DR ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer

We produced SnCE1-SUMO1-PA protein in a preparative scale as described earlier 57,62