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MBio 8 , (2017)

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Clinical studies have not demonstrated evidence of toxic accumulation or progressive increases in drug levels beyond the expected steady-state plateau

doi: 10.1016/j.jep.2016.08.047

Marked erythropoietic activity : Another variant of functional iron deficiency occurs in dogs with strongly regenerative anemias, where the rate of red blood cell production is thought to exceed the ability of macrophages to release iron quickly enough, resulting in iron-deficient erythropoiesis (Schaefer and Stokol 2016)