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However, pharmacological inhibition of the AMPK pathway abolished the antioxidant effect of AM1638

Curr Med Res Opin 2005;21:2:255-60

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AnttilaVWinsvoldBSGormleyPKurthTBettellaFMcMahonGet al

Saulnier et al., 2013)

In addition, interventions that reduce intrahepatic triglyceride content through modest weight loss or leptin treatment dramatically reverse hepatic insulin resistance in T2DM, NAFLD, and lipodystrophic patients [83]