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Porter TG, Martin DL

Noel C, Copin MC, Hazzan M, Labalette M, Susen S, Lelievre G et al

But: metformin can paradoxically inhibit mitochondrial function in complex I, the relationship with NAD+ is complex and requires careful research design

An elevated level of H 2 O 2 can lead to the synthesis of organic peroxides and hydroperoxides other reactive oxygen derivates

Subsequently, it remotely activates alveolar macrophages, promotes the formation of neutrophil extracellular traps, and disrupts the balance of regulatory T cells/Th17 cells, ultimately exacerbating lung injury