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If one study was 15 seconds, where they did serial biopsies on a mouse

In the four-year follow-up, the proportions of VR and BR increased, to 95.7%/81.1%, 96.3%/80.9%, 97.8%/83.2%, 97.8%/82.1%, and 98.9%/83.5% at month 6, year 1, year 2, year 3, and year 4, respectively

Nov 7 2021;18(21)doi:10.3390/ijerph182111693

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Paul Glezen, Rebecca Brady, Robert Frenck, David Bernstein, Christopher Harrison, Mary Anne Jackson, Douglas Swanson, Jason Newland, Angela Myers, Robyn A

The excessive infiltration of SMs into synovia causes articular immune dysfunction, accelerates the progression of synovitis, and leads to osteoclast activation and ultimate bone erosion and joint destruction 7,8