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Moreover, the availability of pharmacological agents capable of selectively regulating lipid metabolism with high precision remains limited due to the highly interconnected nature of lipid metabolic processes and their complex regulatory networks [113]
For example, the spacer can be selected from the group consisting of -C1-C10 alkylene- , -C1-C10 heteroalkylene-, -C3-C8 carbocyclo-, -O-(Ci Cs alkyl)-, -arylene-, -C1-C10 alkylene-arylene-, -arylene-C-i-C-io alkylene-, -C1-C10 alkylene-(C3-Cs carbocyclo)-, -(C3- Cs carbocyclo)-Ci-Cio alkylene-, -C3-C8 heterocyclo-, -C1-C10 alkylene-(C3- Cs heterocyclo)-, -(C3-C8 heterocyclo)-Ci-Cio alkylene-, -C1-C10 alkylene-C(=O)-, -C1- C10 heteroalkylene-C(=O)-, -C3-C8 carbocyclo-C(=O)-, -O-(Ci-Cs alkyl)-C(=O)-, -arylene- C(=O)-, -C1-C10 alkylene-arylene-C(=O)-, -arylene-Ci-Cw alkylene-C(=O)-, -C1- C10 alkylene-(C3-C8carbocyclo)-C(=O)-, -(C3-C8 carbocyclo)-Ci-Cio alkylene-C(=O)-, - C3-C8 heterocyclo-C(=O)-, -C1-C10 alkylene-(C3-C8heterocyclo)-C(=O)-, -(C3- Cs heterocyclo)-Ci-Cio alkylene-C(=O)-, -C1-C10 alkylene-NH-, -C1-C10 heteroalkylene- NH-, -C3-C8 carbocyclo-NH-, -O-(Ci-Cs alkyl)-NH-, -arylene-NH-, -C1-C10 alkylene- arylene-NH-, -arylene-Ci-Cw alkylene-NH-, -C1-C10 alkylene-(C3-Cs carbocyclo)-NH-, - (C3-C8 carbocyclo)-Ci-Cio alkylene-NH-, -Cs-Csheterocyclo-NH-, -C1-C10 alkylene-(C3- Cs heterocyclo)-NH-, -(C3-C8 heterocyclo)-Ci-Cio alkylene-NH-, -Ci-Cwalkylene-S-, -C1- C10 heteroalkylene-S -, -Cs-Cscarbocyclo-S -, -O-(Ci-Cs alkyl)-)-S -, -arylene-S-, -C1-C10 alkylene-arylene-S-, -arylene-Ci-Cw alkylene-S-, -Ci-Cio alkylene-(C3-Cs carbocyclo)-S- , -(C3-C8 carbocyclo)-Ci-Cio alkylene-S-, -C3-C8 heterocyclo-S-, -C1-C10 alkylene-(C3- Cs heterocyclo)-S-, -(C3-C8 heterocyclo)-Ci-Cio alkylene-S-, -C1-C10 alkylene-O-C(=O)-, -C3-C8 carbocyclo-O-C(=O)-, -O-(Ci-Cs alkyl)-O-C(=O)-, -arylene-O-C(=O)-, -C1- C10 alkylene-arylene-O-C(=O)-, -arylene-Ci-Cw alkylene-O-C(=O)-, -C1-C10 alkylene- (C3-C8carbocyclo)-O-C(=O)-,-(C3-C8 carbocyclo)-Ci-Cio alkylene-O-C(=O)-, -C3- Cs heterocyclo-O-C(=O)-, -C1-C10 alkylene-(C3-C8heterocyclo)-O-C(=O)-, and -(C3- Cs heterocyclo)-Ci-Cio alkylene-O-C(=O)-
These data suggest GSTP1 palmitoylation is more stable and less dynamic than other palmitoylated proteins
doi: 10.3389/fonc.2020.01539 Received 31 May 2020 Accepted 19 July 2020 Published 28 August 2020 Volume 10 - 2020 Edited by Bruno Sainz Jr., Autonomous University of Madrid, Spain Reviewed by Patricia Sancho, University of Zaragoza, Spain
PBD dimers show extreme potency but hepatotoxicity concerns in CRC, DXd-based ADCs demonstrate particular promise given their superior immunogenic cell death induction and favorable safety profiles, making them ideal for immunotherapy combinations (36)
