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reported that lactic acid levels in arterial blood and cerebrospinal fluid (CSF) increased after epileptic seizures, but the levels of both returned to normal after 4 days ( Figure 2E ) and zonisamide (the chemical structure is shown in Figure 2F ) cause metabolic acidosis before, during, and after surgery (craniotomy in patients with epilepsy) ( 3.4.4 Epilepsy and adenosine triphosphate Sanders et al