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These side effects were also seen in trials of the FGF19 analog, aldafermin (306)

Meltzer et al., 2020)

monocytogenes increase tolerance to copper and iron stress, suggesting that GSH chelates or buffers excess metal ions to prevent toxicity

Figure 4 Alterations in the intracellular redox status are often associated with GSH depletion (Polonikov, 2020) and endogenous GSH deficiency, due either to decreased biosynthesis and/or increased consumption, is a marked contributor to the pathogenesis of numerous diseases via mechanisms including oxidative stress and inflammation

Novel research directions and future perspectives Metabolomics and multi-Omics approaches The integration of metabolomics with other omics technologiesgenomics, transcriptomics, proteomics, and epigenomicsis providing unprecedented insights into the metabolic vulnerabilities of NSCLC and enabling precision medicine approaches

234 Conversely, knock-down of ZnT3 results in an up-regulation of ZnT8 expression, and vice versa