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The neuroinflammatory response involves the activation of microglia, astrocytes, endothelial cells of the blood-brain barrier, and peripherally-derived immune cells [4, 5]

for instance, catechol oxidation produces hydrogen peroxide (H 2 O 2 ), electron transfer from PDA to molecular oxygen (O 2 ) produces superoxide anions, and catechol oxidation forms hydroxyl radicals (OH) and, rarely, singlet oxygen ( 1 O 2 )

A limitation of this approach is that the reference population needs to consist of a healthy population

Then, the supernatant was re-centrifuged at 12,000 g for 10 min

doi: 10.1002/mds.26431 8 BraakHTrediciKDRbUde VosRAISteurENHJBraakE

Informed consent All subjects and/or their guardians provided informed consent to participate in the study