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More help Life Stage Applicability The life stage for which the AOP is known to be applicable

HD brains exhibit reduced activity of mitochondrial complexes II and III, leading to diminished ATP production and increased ROS, which exacerbate neuronal vulnerability [93]

GDNF and protection of adult central catecholaminergic neurons

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Based on the urgent need for new therapies, Penzes team developed a derivative of an insulin-like growth factor-binding protein, IGFBP2, which is found in structures of the brain affected in ASD and has been shown to improve neuroplasticity and cognitive functions