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Marko Antunovic, Departments of Pharmacology and Pathology, Medical Faculty University of Zagreb, Zagreb 10000, Croatia

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This is the second head-to-head study after Eli Lilly registered its intent to carry out a Phase 3b clinical trial in April 2023 that will see the companys tirzepatide (Mounjaro) compared with Novo Nordisks semaglutide (Wegovy) 2.4mg in 700 adult participants who have obesity or overweight with weight related comorbidities without Type 2 diabetes

25 Since PINK1 promotes mitophagy and USP30 inhibits it, both have become key targets for small molecule intervention

But compared to the Cont group, they are smaller and have weaker myelin sheaths