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Selective and persistent activation of extracellular signal-regulated protein kinase by nitric oxide in glial cells induces neuronal degeneration in glutathione-depleted midbrain cultures

Researchers favor this approach for its accessibility, well-documented protocols, and compatibility with diverse biological sample types including cell lysates and tissue homogenates

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One commenter recommended the DC Function measure under the condition that it be reviewed and refined such that implementation would support patient autonomy and result in care that aligns with patients' personal functional goals

In this report a recommendation was made that toxicity tests should be used, not to attempt to reproduce field exposures, but to develop a consistent means of using toxicity metrics, such as HC 5 and LC 50 for toxicity models used with fate and transport models to compare the exposure and toxicity of various response options, including dispersants (NASEM, 2020)

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