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However, ultra-high-dose methylcobalamin therapy may improve the prognosis of patients with ALS, if administered early in the disease course, the researchers wrote

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Advise males with female partners of reproductive potential to use effective contraception during treatment with pemetrexed and for 3 months after the last dose [see Use in Specific Populations (8.1, 8.3) and Clinical Pharmacology (12.1)]

Only trained professionals should handle this peptide in controlled lab settings