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Description

Mianserin, a tetracyclic antidepressant, has been shown to inhibit tumor growth in SW480 cells in vitro and in vivo through ASCT2 inhibition ( 3.3 Glutamate dehydrogenase (GLUD/GDH) inhibitors Glutamine is enzymatically converted to glutamate by glutaminase, and further conversion of glutamate to -KG is facilitated by GLUD through oxidative deamination (Yoo et al., 2020)

Also, excessive oxidant stress from pollutants can damage DNA and impair sperm function

"Differential regulation of androgen and glucocorticoid receptors by retinoblastoma protein"

Furthermore, metadata from integrated reference datasets, including adult samples (GSE150728) and healthy pediatric samples (GSE135779), were used to further refine cluster annotations