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Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons

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HES (for 10 days) to CIPN rats significantly reduced PTX-induced increases in MDA, NF-B, IL-1, TNF-, COX-2, nNOS, JAK2, STAT3, and GFAP levels with neuropathic pain and alleviated endoplasmic reticulum stress (ERS) [133]

The proportion of CD40+ mucosal macrophages is increased in inflammatory bowel disease whereas CD40 ligand (CD154)+ T cells are relatively decreased, suggesting differential modulation of these costimulatory molecules in human gut lamina propria

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Under GF conditions, uveitis could be alleviated, but the disease still progressed after cohousing with SPF mice (102)