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This vulnerability is further complicated by the blood-brain barrier (BBB), which tightly regulates iron influx and efflux, creating distinct compartmentalization of iron metabolism [10]

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Acknowledgements The authors thank colleagues from the Kiess laboratory for valuable discussions and acknowledge support from the German Diabetes Society, the German Competence Network Obesity, the Federal Ministry of Education and Research (grant 01GI1330 to A.G.), the Mitteldeutsche Kinderkrebsstiftung, the University of Chieti, Italy (for a scholarship to T.d.G.) and LIFE (Leipzig Research Centre for Civilization Diseases, University of Leipzig, Germany)