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Unlike homologous self-assembly in single-herb decoctions or limited interaction networks, multi-herb formulas exhibit substantially greater constituent diversity and interaction complexity

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FLAG-tagged proteins were directly visualized using HRP-conjugated M2 anti-FLAG (Abcam, RRID: AB_869428) or indirectly by combining M2 anti-flag (Sigma-Aldrich catalog number F3165, RRID: AB_259529) and anti-mouse-HRP (Abcam catalog number ab6808, RRID: AB_955441)

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This is consistent with previous findings that -cell plasticity occurs in common forms of -cell dysfunction, and is caused by the downregulation of FoxO1 that follows hyperglycemia-induced oxidative stress 26

Protein kinase C-mediated phosphorylation of the mu-opioid receptor and its effects on receptor signaling