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Nevertheless, in animals subjected to CSD and received ALA administration, the levels of all above signaling proteins were noticeably reduced to near the control values (Figure 5A)

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Importantly, benfotiamine was effective in suppressing cognitive decline, as measured by Alzheimers disease assessment scale and clinical dementia rating

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Halvey PJ, Hansen J, Johnson J M, Go YM, Samali A, Jones DP (2007) Selective Oxidative Stress in Cell Nuclei by Nuclear-Targeted D-Amino Acid Oxidase