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However, successful clinical translation will require addressing persistent challenges, including biosafety, biodistribution, tumor heterogeneity, and large-scale manufacturability

While NAMPT activators show promise in preclinical studies, they are yet to enter clinical trials

The intestinal inflammatory infiltrate consists mainly of CD4 + T cells, regulatory T cells (Tregs), and central memory T lymphocytes (Zhong et al., 2020)

Toxicol Appl Pharmacol 261:1818 Steele ML, Fuller S, Patel M, Kersaitis C, Ooi L, Mnch G (2013) Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells

Direct hepatic toxicity Cytochrome P450 iron porphyrin proteins (CYP) are significant players in oxidative and reduction reactions required for drug metabolism, leading to the formation of polarized ions, oxygen free radicals, and more reactive compounds