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However, NRF2 regulates a plethora of target genes involved in iron metabolism [ FTH1 , FTL , SLC40A1 (FPN), HMOX1 , ABCB6 , FECH , SLC48A1 , BLVRA/B , and HO-1 ], intermediate metabolism [ NROB2 (SHP), PPARG , AKR1C1-3 , G6PD , AKR1B1 , and ALDH1A1 ], and GSH metabolism ( GPX4 , SLC7A11 , GCLC/GCLM , GSS , GSTA1 , GSTP1 , PRDX1/6 , and TXNRD1 ) ( FIGURE 4 Another pathway that regulates GPX4 is the system X c -Gys-GSH redox axis

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(54) demonstrated that quercetin alleviates zearalenone-induced apoptosis and necroptosis in porcine renal epithelial cells by inhibiting the calcium-sensing receptor/calciumcalmodulin-dependent protein kinase II signaling pathway and by protecting the cells from oxidative damage caused by zearalenone exposure

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Moreover, another study from the group led by Imai S showed that NMN can partially attenuate physical activity deficits in adipocyte-specific Nampt knockout mice [36]