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J Psychopharmacol 2014;28(5):40339

This study demonstrated that shikonin inhibited the growth of A375-S2 cells in a time- and concentration-dependent manner, with a 48-hour IC50 value of 7.1 0.9 mol/L (Wu et al., 2004)

doi:10.3389/fphar.2021.729950 Gao Y, Chu S, Li J, Li J, Zhang Z, Xia C,

Smith EB

241 Similarly, natural compounds such as spermidine and resveratrol inhibit p300 activity, leading to global hypoacetylation and activation of autophagy

TGF-1s pro-fibrotic effects are equally evident in the lungs, liver, kidneys, and brain microvasculature, where it promotes type I and III collagen deposition, elastin crosslinking, and the accumulation of -smooth muscle actin (-SMA)-positive myofibroblasts