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Coskun 2022 mmc3 Table 3 + mmc1 Table S8 Phase 1 single-ascending-dose study (NCT03841630, n=45, conducted in Singapore)

[PubMed: 25591052] 2

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The ATTAIN program encompasses multiple Phase 3 trials in obesity (ATTAIN-1, ATTAIN-2, ATTAIN-3, ATTAIN-MAINTAIN), while the ACHIEVE program covers type 2 diabetes indications (ACHIEVE-1 through ACHIEVE-5, plus regional studies)

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But randomized controlled trials of these molecules, which suppress inflammation throughout the body, were abandoned because they showed no clear benefit