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doi: 10.1016/j.bbcan.2022.188837 216 LavianoACascinoAMuscaritoliMFanfarilloFRossi FanelliF

Oxcarbazine (and, more specifically, its active metabolite MHD): Primary mechanism: blocks voltage-sensitive sodium channels, inhibiting repetitive neuronal firing

This made it difficult to perform a radical operation in the delayed period, since it was impossible to cosmetically remove the patch, and in addition, at the site of tension of the sutured tissues (and tension during such interventions almost always occurs, even if the intra-abdominal pressure is not exceeded), there was a risk of infection, after which severe paraprosthetic purulent complications developed

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