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Metabolism of [U- 13 C 5 ] glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling

In MCF-7 breast cancer cells, PYC exerted strong pro-apoptotic and anti-migrative effects, characterized by reduced cell viability, chromatin condensation, and downregulation of genes such as B-cell lymphoma 2, vascular endothelial growth factor (VEGF)/fibroblast growth factor, and p53

Dysregulated Wnt/-catenin and PI3K/Akt pathways form positive feedback loops with lipid metabolism, further promoting tumor growth and survival

10.1016/j.semcdb.2017.05.023 91 MungrueI

This may be attributed to irregular EV secretion resulting from acidic conditions and hypoxia

Furthermore, it highlights the potential for clinical trials targeting mitochondrial function as a therapeutic strategy