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Van Schie: We wondered whether this restricted response is due to the nature of the anti-TNF binding site, or that the antigen binding site is an inherently immunodominant part of the antibody

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An Egyptian study on forty type 1 diabetic patients revealed a significant increase in CD95 percentage expression in DM1 in comparison to controls and they explain that by that the findings of immunological, inflammatory and metabolic signals leading to -cell apoptosis were increased in diabetic patients and they proposed that these signals converge toward a common -cell death signaling pathway (Sherif et al ., 2005)

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