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doi: 10.1254/jphs.13R01CP 123 BerruyerCMartinFCastellanoRMaconeAMalergueFGarrido-UrbaniSet al

The compounds safety and pharmacological profile have been comprehensively assessed in rodent models.In preclinical trials, including those involving ovariectomized (OVX) rat models, both low- and high-dose AOD-9604 regimens showed no significant toxicity

Proper labeling prevents dosing mistakes during repeated solution preparation processes

It interacts with DNA to form adductssuch as DNADNA and DNAproteins crosslinkswhich activate several signal transduction pathways that trigger cell death 74,76