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Multiple infusions may be required and there may be recommended intervals between infusions

When the immune system is constantly fighting an invisible enemy, it generates massive amounts of reactive oxygen species (ROS) as a byproduct

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This compensatory mechanism, however, has a narrow therapeutic window as prolonged exposure remains detrimental

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For example, IL-4 expression by microglia suppresses the release of proinflammatory cytokines such as IL-6, TNF-, or NO, contributing to the transition of microglia toward the neuroprotective phenotype (Park et al., 2005