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However, side effects and complications can include: itchy skin low blood pressure slowed breathing loss of bladder control fever flushed chest or face anxiety difficulty sleeping changes in the menstrual cycle diarrhea nausea temporary increase in blood sugar In severe breathing difficulty nerve damage prolonged numbness abscesses bleeding allergic reaction adrenal suppression epidural bruising infection spinal headache pain in the lower limbs or back paralysis Doctors may use a nerve block spinal injection to treat acute or chronic pain that may originate in the spine and can radiate to the arms, legs, buttocks, and neck

Dose optimization depends on specific research objectives, administration route, and whether acute effects or long-term structural changes are being measured

[DOI] [PubMed] [Google Scholar] 54.Kokot A, Zlatar M, Stupnisek M, Drmic D, Radic R, Vcev A, Seiwerth S, Sikiric P

N., Geng, X., Bauer-Marschallinger, B., Guevara, M

[] In contrast, other studies have indicated that L-OPA1 alone may be sufficient under certain conditions

Animal studies suggest relatively rapid distribution following injection, with activity observed at both local and systemic sites