glutathione levels in cancer patients peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression thyroid Clinical studies of glutathione levels

J Oral Rehabil 2023;50(9):792-801 Briana N Sprague, Xiaonan Zhu, Andrea L Rosso, Joe Verghese, Kim Delbaere, Darren M Lipnicki, Perminder S Sachdev, Tze Pin Ng, Xinyi Gwee, Keng Bee Yap, Ki-Woong Kim, Ji Won Han, Dae Jong Oh, Kenji Narazaki, Tao Chen, Sanmei Chen, Henry Brodaty, Katya Numbers, Nicole A Kochan, Richard W Walker, Stella-Maria Paddick, Oye Gureje, Akin Ojagbemi, Toyin Bello, Caterina Rosano, COSMIC Consortium Correlates of Gait Speed Among Older Adults From 6 Countries: Findings From the COSMIC Collaboration

Int J mol Sci

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Chen L, Hambright WS, Na R, Ran Q (2015) Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis

Most cases are associated with mutations in the SLC39A4 gene on chromosome 8

This physical deconditioning accelerates muscle atrophy, creating a vicious cycle: the less muscle mass a patient has, the more exhausting simple physical tasks become, leading to further inactivity and further muscle loss