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Using this as a principle, in case of small-molecule thiols, it has been demonstrated that higher p K a often implies higher reactivity [172]

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41 In a more recent meta-analysis, there were no differences between operative and nonoperative approaches in short-term functional outcomes at 6 months, and there were increased complications in patients treated surgically

Generally, the entire process from linker design and synthesis to provision of preliminary samples takes about 4 to 8 weeks