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The pituitary gland: Inflammation here (hypophysitis) might cause headaches, hormonal problems, and other symptoms

However, the cellular stress of the upstream events, i.e., reactive metabolite formation, GSH depletion, and protein adducts formation, is still present and this stress may trigger apoptosis in a limited number of cells (Figure 1)

What we can assess: For a cost-effectiveness perspective, a published analysis found tirzepatide to be the most cost-effective option compared to oral semaglutide, with an incremental cost-effectiveness ratio of $34,212 per QALY gained