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Notably, the treachery of MANF, an initial liver protective factor, in ICC is a representative regulatory mechanism of body, which opens the doors for potential diagnosis and treatment of ICC (Fig

Recent studies have shown that glutathione not only affects normal immune function but also participates in complex immune reactions such as fever

Glutamate toxicity can also trigger calcium influx that leads to mitochondrial calcium overload [12] whereas, once fragmented, mitochondria reduce their calcium buffering capacity [49]

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Acknowledgments The authors thank Regi Mathew for providing patient data and Jon Hernandez for coordinating the transportation of samples from patients rooms to research laboratories