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Kimura and Higaki 2002

The unimolecular approach is simpler but less flexible

NAD is not a peptideit's a dinucleotide coenzyme made of two nucleotides, not amino acids linked by peptide bonds NAD+ serves dual roles: facilitating energy production through redox reactions and acting as a substrate for DNA repair enzymes Age-related NAD+ decline contributes to cellular dysfunction, but restoring levels may slow aging and improve health outcomes NAD+ supplements have questionable effectiveness due to poor bioavailability and potential disruption of natural biochemical balance The NAD+/NADH ratio is crucial for metabolic regulationthese are two forms of the same molecule, not separate compounds This essential coenzyme participates in over 300 enzymatic reactions, making it fundamental to cellular metabolism, DNA repair, and healthy aging processes throughout the body

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doi: 10.1210/jc.2006-1706