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doi: 10.3389/fendo.2022.945578 Received 16 May 2022 Accepted 05 October 2022 Published 20 October 2022 Volume 13 - 2022 Edited by Tiziano Baroni, University of Perugia, Italy Reviewed by Sahar Houshdaran, University of California, San Francisco, United States

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Common drugs and mechanism of DILI Anti-TB drugs Antituberculosis DILI (ATDILI) is a common form of DILI that often leads to the interruption of tuberculosis treatment and hinders the treatment process

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elegans occurs downstream of glutathione depletion, consistent with its effect in rescuing ferroptosis in cultured cells 32

PMID: 33711021 Keywords Alpha Sympathomimetics Brimonidine Trade Names: Alphagan-P, Qoliana, Lumify & generic FDA approved in 1996 Drug Class: Alpha-2 Selective Adrenergic Agonist, Antiglaucoma, Vascular decongestant Mechanism of Action: 2 adrenoreceptor agonist approximately 10-times more selective for alpha-2 receptors compared to clonidine (Cambridge, 1981) does not exhibit significant tachyphylaxis with repeated use (Lee & Kim, 2022) Indications: Prescription & OTC to treat symptoms of: open-angle glaucoma : to lower intraocular pressure or ocular hypertension (Alphagan-P, Qoliana )