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doi: 10.1038/s41401-022-00874-x

Among the primary human classes of this system, GSTM1 and GSTT1 genes exhibit a deletion polymorphism that leads to a lack of active isoforms when in homozygosis, known as the null genotype [9]

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Alkyl glycosides to be used as permeation enhancer in the present invention can include, but are not limited to: alkyl glycosides, such as octyl-, nonyl-, decyl-, undecyl-, dodecyl-, tridecyl-, tetradecyl-, pentadecyl-, hexadecyl-, heptadecyl-, and octadecyl-a- or p-D-maltoside, -glucoside or -sucroside (which may be synthesized according to Koeltzow and Urfer