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Research suggests that disturbances in iron homeostasis might initiate considerable oxidative stress and inflammatory reactions, resulting in neuronal damage and exacerbating the progression of AD [62, 63]

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In the absence of SPRTN, these persistent DPCs lead to DNA damage and mutagenesis, likely contributing to the development of hepatocellular carcinoma in patients with Ruijis-Aalfs syndrome

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LiL.KaplanJ.1998Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity.2218122187, ISSN0021-9258 72